Alpha-2-Macroglobulin Therapy (A2M)

What is A2M?

A2M, also known as alpha-2-macroglobulin is made in the liver and naturally found in high concentrations in the blood. As a large plasma protein, it works by targeting proteins that attack the cartilage found in joints, like white blood cells role in infection.

A2M injections can provide relief for the following conditions:

  • Osteoarthritis
  • Tendonitis
  • Post-Traumatic Arthritis
  • Rheumatoid Arthritis
  • Gout
  • Ligament injuries


When a patient suffers from arthritis, their joints are affected by chemicals such as cytokines, matrix metalloproteinases and proteases that degrade cartilage. These catabolic proteases cause cartilage to deteriorate, leading to pain and inflammation. Over time, the disease can erode cartilage entirely, resulting in painful bone-on-bone friction. In healthy joints, cartilage acts as a cushion to prevent such contact.

Alpha-2-Macroglobulin (A2M) intervenes in the progression of osteoarthritis at a molecular level by deactivating the chemicals responsible for joint breakdown. By capturing and neutralizing these harmful substances, A2M enables the body to eliminate them. Consequently, inflammation subsides, and the joint can begin to heal without the presence of damaging chemicals. A2M remaining in the joint promotes tissue growth, facilitating the restoration process. Ultimately, repaired damage leads to a joint free from pain.

The procedure is simple. Blood is drawn from the patient and after a specialized centrifugation process, the plasma component is drawn out and the A2M filtered and concentrated. The A2M rich injectate is then injected to affected sites, usually a joint: hip, shoulder, knee, etc.

A2M injections have shown promise in addressing arthritis-related pain and damage in some patients. Research suggests that initiating the joint restoration process early in arthritis treatment may offer the best chance of protecting cartilage before significant damage occurs. However, it’s important to note that the effectiveness of A2M injections may vary among individuals, and outcomes may differ depending on the severity of the condition.

It’s important to remember that the information provided here is based on available research and patient experiences, and individual results may vary. As always, patients should consult with their healthcare provider for personalized recommendations and guidance regarding arthritis management.